eNOS GENE VNTR POLYMORPHISMS ARE ASSOCIATED WITH ORAL CYST
DOI:
https://doi.org/10.71336/jabs.922Keywords:
eNOS, VNTR, oral cyst, PCR, polymorphismAbstract
Odontogenic cysts are originated from maxillary and mandibular teeth bearings odontogenic tissue and pathological cavities which are surrounded by fibrous connective tissue with epithelial layers. Cystic conditions on the jaw would end up bone damage, reabsorption or loss of the related tooth. Odontogenic cysts may occurdevelopmental, or inflammation-related. They are more common in adults than in pediatrics. Reports shows that matrix metalloproteinase synthesis which is activating by Nitric Oxyde (NO) participates bone resorption and cyst enlargement due to high NO production. eNOS gene variants change gene expression and activity due to increasing or over NO production and this situation causes various pathological conditions. The aim of this study is to investigate eNOS gene VNTR 4b/4a variants and oral cysts possible relationships. Genotyping revealed by the PCR method and 31 patients have I/I, 5 patients I/D, 1 patients D/D genotype with a total of 37 patients in the experiment group. According to obtained results, eNOS variantsI/I alleles and genotype frequency patients have more oral cyst possibility than D/D allele and genotype patients. Current results show that eNOS polymorphism may represent possible risk factors for the oral cyst.
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